• Introduction The role of a surgical

  2018-11-12

  

  Introduction The role of a surgical margin in surgical oncology has always been discussed with regard to the tumor recurrence and survival rate in gastrointestinal cancer surgery. Previous reports have suggested that extensive operation with a wide resection margin and extensive phosphodiesterase i

• Forehead osteomata can be removed by burring

  2018-11-12

  

  Forehead osteomata can be removed by burring or osteotome chiseling. Comparing these two methods, bone burring is not an efficient method for removing osteomata. It also increases the risk of soft tissue injury or a depressed bony surface. Removal of an osteoma by a curved osteotome is, however, bot

• cholecystokinin receptor br Key problems that need to be res

  2018-11-12

  

  Key problems that need to be resolved to understand the relationship between foods and health In term of the relationship between foods and health, the following four key problems have to be addressed: (1) Undernutrition causes nutrition deficiency, and overnutrition leads to obesity, hypertensio

• AUY922 br Materials and methods br Data analysis All results

  2018-11-12

  

  Materials and methods Data analysis All results are presented as means±SEM. Comparisons between groups were analyzed using t-tests (two-sided). Differences with p values of less than 0.05 were considered significant. The p values were corrected for multiple testing procedures and to control ty

• LDS BBs were found to

  2018-11-12

  

  LDS BBs were found to respond to ET-1 stimulation with a decrease in cell shortening. Furthermore, our findings that BQ123, but not BQ3020, blocked the negative shortening response to ET-1 are consistent with those of Izumi and co-workers (Izumi et al., 2000) and indicate an ETA receptor-mediated ef

• Regarding JNK phosphorylation levels were either moderately

  2018-11-12

  

  Regarding JNK, phosphorylation levels were either moderately (for JNK 1) or significantly increased (for JNK 2/3) at 5μM SB203580 compared to DMSO controls; these effects were further pronounced at 30μM (Figs. 5 A–B, schema in Figs. 6 C–D). This suggests a concentration-dependent activation of JNK

• We derived ESC lines from

  2018-11-12

  

  We derived ESC lines from blastocysts of the double transgenic mouse line Mlc2v-Cre; Rosa26-Yfp, in which Cre and Yfp are specifically knocked into the Mlc2v and Rosa26 gene loci, respectively. Mlc2v-Cre-mediated removal of a stop sequence in the Rosa26-YFP reporter line results in expression of YFP

• Most published protocols for the

  2018-11-12

  

  Most published protocols for the endothelial differentiation of hESCs employ stromal co-culture (Boyd et al., 2007; Vodyanik et al., 2005) or utilise media with undefined or animal derived components such as serum, albumin fractionated from bovine serum, conditioned media or extracellular matrices (

• Both Brat and Mei P belong to the Trim

  2018-11-12

  

  Both Brat and Mei-P26 belong to the Trim-NHL family of proteins, which have conserved functions in stem cell lineages from C. elegans to mouse (for review, see Wulczyn et al., 2010). Proteins within this family are potential E3 ubiquitin ligases and can act by either activating or antagonizing the m

• In hematopoietic systems individual blood progenitor

  2018-11-12

  

  In hematopoietic systems, individual blood progenitor ionomycin each appear to have their own proliferation program with “self-replication potential.” Identification of the self-replication factors in lineage blood progenitors should enable immortalization of the cells. With that in mind, we have b

• Modulation of GASZ by ectopic overexpression or by RNA

  2018-11-12

  

  Modulation of GASZ by ectopic overexpression or by RNA interference in ESCs affected several key germ cell markers, such as Oct4, Dazl, Mvh, Miwi, and Mili, which may in turn contribute to the altered PGC or EGC derivation from differentiated EBs. Since GASZ is localized in the intermitochondria cem

• Although H AZK me could be

  2018-11-12

  

  Although H2AZK7me1 could be detected by ChIP at the transcriptional start site of a few differentiation markers (Fgf5, FoxA2, and Hand2) in E14 mES cells and the level of methylation decreased from those genes in response to retinoic acid-induced differentiation, we still do not know what H2AZK7me1

• Intrinsic factors that induce neurogenesis include neurotrop

  2018-11-12

  

  Intrinsic factors that induce neurogenesis include neurotrophins and neuropeptides, which are released by neuronal activity. Two specific factors, neuropeptide VGF (non-acronymic) and Brain-Derived Neurotrophic Factor (BDNF) have received attention in the context of their contribution to either prol

• Introduction The mechanisms by which pluripotency regulators

  2018-11-12

  

  Introduction The mechanisms by which pluripotency regulators dictate self-renewal versus differentiation are only recently being studied (Wagner et al., 2010; Niwa et al., 2009). In addition, various approaches are being developed to examine such processes (Wang et al, 2013). The transcriptional re

• br Material methods br Results br Discussion Several LSC

  2018-11-12

  

  Material & methods Results Discussion Several LSC culture systems have been developed to re-create the LSC niche in vitro and to avoid the cross-contamination with non-human feeder xpo 1 (Sharma et al., 2012; Xie et al., 2012; Chen et al., 2013; Mei et al., 2014). It has been suggested that

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